Deficiency of B vitamins and folic acid in maternal diet is another commonly associated cause of cleft lip and palate in the new born.
Parents who are older than usual at the time of birth of their baby are at higher risk of having children with cleft lip and or palate.
A viral infection during pregnancy may also be associated with cleft lip and palate. Mothers who are obese have a higher chance of their child being born with a cleft. ~Source
B group vitamins including folic acid supplementation during pregnancy have been shown to be effective in preventing cleft lip and palate (CLP) in humans. ~Source
Exposure to benzodiazepines during pregnancy has been associated with a slightly increased risk of cleft palate in newborns. ~Source
Nicotinic Acid or Niacin is converted to NAM, which has benzodiazepine-like actions in the gamma-aminobutyric acid (GABA) system. ~Source
Therefore…Benzodiazapine’s cause a B vitamin complex deficiency.
PDF: Case report of mental disorder induced by niacin deficiency
Summary: The 45-year-old male patient described in this case report had a classic case of pellagra. The patient was initially brought to a psychiatric hospital because of disorderly behavior. On admission the patient was unable to provide a history so he was given a provisional diagnosis of Psychosis Not Otherwise Specified. Despite having the cardinal symptoms of dermatitis, dementia and (three days after admission) diarrhea it took 20 days to confirm the diagnosis of pellagra. After initiation of appropriate treatment it took about six months for the patient to make a complete recovery.
Case Report – Status on admission.
A 45-year-old male was admitted in April 2011 after being found lying naked in the street talking to himself and cursing passers-by. He was unable to provide his name or home address so no information was available on his history.
On admission his vital signs were normal (temperature 36.5 °C; pulse, 80 bpm; respiratory rate, 20 times/minute; and blood pressure, 125/80 mmHg) and he had normal muscle strength and reflexes. There were no abnormalities in electrolytes, blood counts, blood glucose, lipid profile, or liver or kidney function tests. Urine and stool tests were normal. EKG, EEG and ultrasound of the liver, kidneys, pancreas and spleen found no abnormalities. The sole abnormality on physical examination was that the skin around his eyes and forehead were dark brown to black and his hands and forearms were covered with flaking skin.
Mental status examination on admission found that the patient was conscious but unable to answer questions correctly. He covered his head with a quilt during the examination for no obvious reason. He laughed to himself, manifested inappropriate emotions and appeared to lack insight into his condition. He had difficulty concentrating, had slowed reactions, and got a score of 20 on the Mini-Mental Status Exam (MMSE)—indicating moderate cognitive impairment.
PDF: To Be or Not To Be Subclinical Pellagra
“To be, or not to be, that is the question.” These words of Shakespeare can be applied to subclinical pellagra. Is it a disease? Is it a syndrome? Is it a deficiency? Is it an allergy? Questions like these are frequently asked by the public, the patient, and doctors too. I believe subclinical pellagra is part of the continuum of mental ill health. It starts with complaints of a minor nature, maybe some behavioral disturbances, and may extend on to the frank psychoses. It is a sounder diagnosis than adolescent behavior syndrome, minimal brain damage, and the like.
Definition: Subclinical pellagra is a syndrome characterized by perceptual changes involving all senses, special and/or proprioceptive. There is also an unusual sensitivity to refined carbohydrates. This combination leads to a variety of symptoms which blanket the field of medical complaints. The administration of niacin causes prompt disappearance of special sense dysfunctions, while proprioceptive sense changes are more slowly corrected with dietary and other measures.
International Society for Orthomolecular Medicine